Fig. 1.

Representative MAP recordings from intrinsically beating KCNE1^−/− hearts Langendorff-perfused with control Krebs–Henseleit solution demonstrating typical spontaneous triggered activity occurring as ectopic MAP waveforms (asterisk) in association with the onset of spontaneous VT (a) in contrast to their absence in similarly perfused intrinsically beating WT hearts (b). Treatment with 20 µM nicorandil reduced both triggered activity and VT in KCNE1^−/− hearts (c). WT hearts treated with nicorandil did not show triggered activity or VT (d)