Table 1.

Ageing promotes a decrease of TLA oxidative fibre proportion, while PPARβ agonist treatment restores a juvenile phenotype

Age in month	2.5 months			22 months
C57Bl6 Mice	Control	GW96h	p value	Control	GW96h	p value
SDH positive (%)	46.4 ± 1.3	54.6 ± 1.9	1.5E−05	39.3 ± 1.4	47.6 ± 2.4	0.0067
SDH negative (%)	53.6 ± 1.3	45.4 ± 1.9	1.5E−05	60.7 ± 1.4	52.4 ± 2.4	0.0067

In situ staining of succinate dehydrogenase activity using cross-sections around mid-portion of the TLA muscles from 10-week-old and 22-month-old animals treated or not for 4 days with GW0742