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. Author manuscript; available in PMC: 2009 Aug 2.
Published in final edited form as: J Nucl Med. 2009 May 14;50(6):999–1007. doi: 10.2967/jnumed.108.059576

TABLE 1.

Requirements for T1 Agents in MRI: Number of Particles Required Scales Inversely with Molarity Within Carrier Particle

Diameter of particle containing 1 M gadolinium solution (nm) [Gadolinium] in tissue (μM) if 1 particle per (100 μm)3 voxel No. of particles per cell to achieve 1 μM to produce Δ R1 ~0.1 s−1 in (100 μm)3 voxel
10 0.5 × 10−6 2,000 every cell
100 0.5 × 10−3 2 every cell
1,000 0.5 1 every 500 cells