. Author manuscript; available in PMC: 2009 Aug 2.

Published in final edited form as: Arch Neurol. 2008 Dec;65(12):1640–1648. doi: 10.1001/archneur.65.12.1640

Table 3.

SORL1 SNPs Showing Association With at Least 1 MRI Trait in the MIRAGE White Families

	P Value (No. of Informative Families)^a
SNP	WMH	CVR	CA	MTA
1	.053 (73)	.046 (73)	.43 (73)	.21 (T^b/73)
6	.03 (66)	.16 (66)	.65 (66)	.18 (T^b/66)
8	.001 (81)	.006 (81)	.35 (81)	.34 (C^b/81)
9	<.001 (76)	.002 (76)	.44 (76)	.29 (G^b/76)
10	.006 (78)	.02 (78)	.94 (78)	.16 (C^b/78)
11	.08 (76)	.42 (76)	.57 (T^b/76)	.050 (T^b/76)
15	.04 (G^b/80)	.47 (80)	.42 (G^b/80)	.12 (80)
16	.33 (A^b/31)	.21 (A^b/31)	.004 (31)	.36 (A^b/31)
18	.15 (29)	.03 (29)	.45 (29)	.98 (29)
21	.38 (G^b/38)	.35 (G^b/38)	.02 (38)	.24 (38)

Abbreviations: CA, cerebral atrophy; CVR, severity rating of cerebrovascular disease; MIRAGE, Multi-Institutional Research in Alzheimer's Genetic Epidemiology; MRI, magnetic resonance imaging; MTA, medial temporal atrophy; SNP, single-nucleotide polymorphism; SORL1, sortilin-related receptor gene; WMH, white matter hyperintensity.

Significant results are given in boldface type.

Indicates major allele associated with increasing MRI trait abnormality.