Figure 1.

Oxidation of DOPAC leads to formation of fluorescent species. A: Fluorescence (excited at360 nm) of freshly prepared DOPAC (short dash); after 4 days of incubation (long dash); and after 1 year of incubation (solid line). DOPAC concentration was 100 μM, excitation was 360 nm. B: Kinetics of DOPAC fluorescence (excitation at 360 nm, emission at 456 nm) on incubation with 70 μM α-synuclein (●); with 5 mM NaN3 (▼); and DOPAC alone (○).