The amino acid sequence of 5-HT2Mac receptor is aligned with the most highly homologous proteins found in each. Heavy lines and roman numerals above the sequence indicate transmembrane regions 1 through 7. Black boxes with white letters represent areas of identical regions, dark gray boxes with black letters represent conserved regions, and light gray boxes with black letters represent blocks of similar regions. Accession numbers are: prawn, EF033662; lobster, AAS57919; fruit fly, NP_649806; mouse, NP_766400; human, NP_000612.