Table 2. Summary of the differential expression analysis in 17 brain areas of controls and suicides with and without major depression.
| Brain Region | Genes analyzed | Genes significant | C-SMD | C-S | SMD-S |
| BA4 (C = 6; S = 5; SMD = 8) | 14632 | 202 | 128 (66 up; 62 down) | 55 (28 up; 27 down) | 62 (35 up; 27 down) |
| BA6 (C = 7; S = 6; SMD = 13) | 15266 | 286 | 216 (105 up; 111 down) | 76 (31 up; 45 down) | 46 (20 up; 26 down) |
| BA8,9 (C = 6; S = 5; SMD = 9) | 14854 | 589 | 73 (33 up; 40 down) | 302 (71 up; 231 down) | 411 (147 up; 264 down) |
| BA10 (C = 6; S = 6; SMD = 7) | 11935 | 636 | 604 (436 up; 168 down) | 41 (30 up; 11 down) | 69 (31 up; 38 down) |
| BA11 (C = 6; S = 5; SMD = 9) | 14410 | 152 | 85 (19 up; 66 down) | 33 (11 up; 22 down) | 77 (50 up; 27 down) |
| BA20 (C = 5; S = 5; SMD = 6) | 13944 | 255 | 77 (36 up; 41 down) | 68 (21 up; 47 down) | 173 (50 up; 123 down) |
| BA21 (C = 9; S = 6; SMD = 5) | 14129 | 204 | 161 (42 up; 119 down) | 20 (8 up; 12 down) | 64 (37 up; 27 down) |
| BA38 (C = 7; S = 5; SMD = 6) | 14395 | 182 | 65 (37 up; 28 down) | 102 (58 up; 44 down) | 64 (16 up; 48 down) |
| BA24 (C = 7; S = 5; SMD = 9) | 15243 | 84 | 52 (27 up; 25 down) | 20 (5 up; 15 down) | 27 (15 up; 12 down) |
| BA29 (C = 8; S = 7; SMD = 10) | 15032 | 83 | 19 (7 up; 12 down) | 40 (13 up; 27 down) | 40 (24 up; 16 down) |
| Amy (C = 8; S = 6; SMD = 14) | 15007 | 153 | 95 (56 up; 39 down) | 47 (22 up; 25 down) | 35 (25 up; 10 down) |
| Hippo (C = 6; S = 6; SMD = 10) | 14495 | 426 | 34 (16 up; 18 down) | 118 (60 up; 58 down) | 359 (196 up; 163 down) |
| NAcc (C = 6; S = 6; SMD = 10) | 15232 | 140 | 22 (8 up; 14 down) | 60 (10 up; 50 down) | 91 (11 up; 80 down) |
| BA44 (C = 12; S = 6; SMD = 13) | 15788 | 140 | 88 (32 up; 56 down) | 24 (15 up; 9 down) | 48 (30 up; 18 down) |
| BA45 (C = 11; S = 6; SMD = 12) | 15886 | 101 | 60 (13 up; 47 down) | 21 (8 up; 13 down) | 27 (17 up; 10 down) |
| BA46 (C = 7; S = 7; SMD = 12) | 15655 | 622 | 140 (37 up; 103 down) | 192 (148 up; 44 down) | 470 (373 up; 97 down) |
| BA47 (C = 9; S = 7; SMD = 12) | 15303 | 163 | 102 (48 up; 54 down) | 29 (13 up; 16 down) | 51 (29 up; 22 down) |
| Total | 251206 | 4472 |
C = control, S = suicide, SMD = suicide with major depression, Amy = amygdala, Hippo = hippocampus, NAcc = nucleus accumbens. Information on Brodmann areas is provided elsewhere93–94. The number of genes analyzed corresponds to the number of genes considered as “Present” by the detection algorithm (MAS 5.1) in at least 75% of subjects in at least one of the groups. The number of genes reported as significant is that obtained in an ANCOVA model which included substance abuse/dependence as a covariate.