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. Author manuscript; available in PMC: 2010 Jun 26.
Published in final edited form as: Mol Cell. 2009 Jun 26;34(6):641–651. doi: 10.1016/j.molcel.2009.04.034

Figure 7. Mechanism of Activating JM Mutations.

Figure 7

A. Contacts between the acceptor JM domain and donor C-lobe are shown with the V665 side-chain represented as space-filling spheres. The V665 side-chain fails to fill a cavity on the donor C-lobe formed by the side-chains of Q788, Y789 and Q825. However, as shown in the right-hand panel, a methionine (red) at position 665 – modeled for this figure - would completely fill the cavity, increasing van der Waal’s contacts between acceptor and donor. B. Similarly, the L679F mutation is likely to promote interactions between the JM region (green) and the donor C-lobe, as indicated by modeling a phenylalanine at this position.