Table 2.
Associations of Intrahepatic cholangiocarcinoma, Extrahepatic Cholangiocarcinoma, Pancreatic Carcinoma, and Hepatocellular Carcinoma with Hepatitis C Virus Infection among Veterans
| Outcome | Events/100,000 person-years (events) |
Hazard Ratios Comparing HCV-infected with HCV-uninfected Veterans |
|||
|---|---|---|---|---|---|
| HCV-infected cohort (N = 146,394) |
HCV-uninfected cohort (N = 572,293) |
HR (95%CI) Adjusted for Matching Variables‡ |
HR (95%CI) Adjusted for Matching Variables‡ and Previous VA Use |
HR (95%CI) Adjusted for Matching Variables, ‡ Previous VA Use, Race, and Era of Military Service |
|
| Intrahepatic cholangiocarcinoma |
4.0 (14) | 1.6 (23) | 2.55 (1.31, 4.95) | 2.38 (1.22, 4.65) | 2.31 (1.18, 4.54) |
| Extrahepatic cholangiocarcinoma |
4.3 (15) | 4.2 (60) | 1.05 (0.60, 1.85) | 1.24 (0.70, 2.20) | 1.25 (0.70, 2.22) |
| Pancreatic carcinoma |
40.3 (140) | 33.5 (477) | 1.23 (1.02, 1.49) | 1.32 (1.09, 1.60) | 1.26 (1.04, 1.53) |
| Hepatocellular carcinoma |
381.6 (1310) | 25.9 (369) | 15.09 (13.44, 16.94) | 14.80 (13.17, 16.63) | 14.75 (13.12, 16.59) |
Note: Hazard ratio, HR; HCV, hepatitis C virus; VA, Veterans Affairs; HCC, hepatocellular carcinoma; ECC, extrahepatic cholangiocarcinoma; ICC, intrahepatic cholangiocarcinoma.
‡
Matching variables include age, sex, baseline visit date, and type of visit (inpatient or outpatient) for the baseline visit and a preceding visit.