Table 3.
Hazard Ratios of Intrahepatic Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma, Pancreatic Carcinoma, and Hepatocellular Carcinoma Among Hepatitis C—infected and Hepatitis C—uninfected Veterans
| Variables for which Hazard Ratios Were Adjusted in Addition to Matching Variables* |
Intrahepatic Cholangio- carcinoma (N = 37) |
Extrahepatic Cholangio- carcinoma (N = 75) |
Pancreatic Carcinoma (N = 617) |
Hepatocellular Carcinoma (N = 1,679) |
|---|---|---|---|---|
| Matching variables only |
2.55 (1.31, 4.95) | 1.05 (0.60, 1.85) | 1.23 (1.02, 1.49) | 15.09 (13.44, 16.94) |
| Acute pancreatitis | 2.39 (1.23, 4.66) | 1.02 (0.58, 1.79) | 1.18 (0.97, 1.42) | 14.97 (13.34, 16.81) |
| Chronic pancreatitis | 2.53 (1.30, 4.92) | 0.99 (0.56, 1.75) | 1.18 (0.98, 1.42) | 15.02 (13.38, 16.86) |
| Alcoholism | 2.49 (1.28, 4.86) | 1.06 (0.60, 1.87) | 1.21 (1.00, 1.46) | 14.92 (13.29, 16.75) |
| Alcoholic liver disease |
2.07 (1.03, 4.16) | 0.72 (0.40, 1.31) | 1.18 (0.98, 1.44) | 12.89 (11.45, 14.50) |
| Cholecystectomy | 2.55 (1.31, 4.95) | 1.05 (0.60, 1.85) | 1.23 (1.02, 1.49) | 15.09 (13.44, 16.94) |
| Choledochal cyst | 2.48 (1.27, 4.83) | 1.05 (0.60, 1.85) | 1.23 (1.02, 1.48) | 15.09 (13.44, 16.93) |
| Choledocholithiasis | 2.48 (1.28, 4.83) | 1.04 (0.59, 1.83) | 1.21 (1.00, 1.46) | 15.07 (13.42, 16.91) |
| Cholelithiasis | 2.45 (1.26, 4.77) | 0.98 (0.56, 1.74) | 1.18 (0.97, 1.42) | 14.75 (13.14, 16.56) |
| Cirrhosis | 2.76 (1.41, 5.41) | 0.60 (0.32, 1.12) | 1.12 (0.92, 1.37) | 12.56 (11.15, 14.14) |
| Diabetes | 2.54 (1.31, 4.94) | 1.04 (0.59, 1.83) | 1.24 (1.03, 1.49) | 15.13 (13.48, 16.99) |
| Hepatitis B virus (HBV) |
2.13 (1.05, 4.29) | 0.95 (0.53, 1.71) | 1.19 (0.98, 1.44) | 14.81 (13.18, 16.63) |
| Inflammatory bowel disease (IBD) |
2.54 (1.31, 4.93) | 1.05 (0.60, 1.85) | 1.23 (1.02, 1.49) | 15.10 (13.45, 16.94) |
| Primary sclerosing cholangitis (PSC) |
2.32 (1.19, 4.52) | 1.05 (0.60, 1.86) | 1.20 (0.99, 1.45) | 15.06 (13.42, 16.91) |
| Diabetes + cirrhosis | 2.75 (1.40, 5.40) | 0.59 (0.32, 1.10) | ||
| IBD + PSC | 2.33 (1.20, 4.55) | 1.05 (0.60, 1.85) | ||
| HBV + cirrhosis | 2.30 (1.13, 4.68) | 0.56 (0.30, 1.06) | ||
| Cirrhosis + alcoholic liver disease + alcoholism |
2.20 (1.09, 4.44) |
Matching variables include age, sex, baseline visit date, and type of visit (inpatient or outpatient) for the baseline visit and a preceding visit.