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. 2009 Aug 12;4(8):e6600. doi: 10.1371/journal.pone.0006600

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Nolan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Patients with sepsis (n = 31) had blood drawn within 24 hrs of ICU admission. Samples analyzed by flow cytometry and plasma underwent cytokine analysis. Panel A-CD14⁺ monocytes expression of CD80 in subjects with (n = 20) or without (N = 10) septic shock. Panel B- Correlation between CD14⁺ monocytes expression of CD80 and SOFA Score. Panel C- CD14⁺ monocytes expression of CD86 in survivors (N = 24) and non-survivors (N = 6). Panel D- Correlation between CD14⁺ monocytes expression of CD86 and ICU Free days. Panel E-CD14⁺ monocytes expression of CD86 in subjects with (n = 16) or without (N = 14) bacteremia on presentation. Panels F and G— Correlation between CD14⁺ monocytes expression of CD86 and IL-6 (Panel F) and IL-10 (Panel G).