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. 2009 Jul 1;119(8):2330–2342. doi: 10.1172/JCI39087

Figure 3. Macrophages are only partially responsible for CSF-1–dependent renal repair.

Figure 3

(A) CD11b-DTR and WT mice were injected with CSF-1 following renal injury. We injected DT to deplete macrophages as indicated in the diagram, and we injected anti–CSF-1R Abs as in the diagram. (B) Tubular pathology (outer medulla) and (E) TEC proliferation were analyzed at days 0, 3, and 5 after I/R. (C) Renal function (albuminuria, BUN), (D) fibrosis (collagen), and (E) tubular apoptosis (caspase-3) were analyzed at day 5 after I/R. Data represent means ± SEM.