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. 2009 Jul 20;119(8):2304–2316. doi: 10.1172/JCI38289

Figure 6. Treatment of mice with CR2-Crry following PHx results in a dose-dependent decrease in hepatic C3d deposition.

Figure 6

WT mice were treated with normal saline or CR2-Crry at a dose of 0.25 mg or 0.08 mg immediately after surgery. C3–/– mice received no treatment. At 48 hours after PHx, livers were removed and sections were analyzed for C3d deposition by immunofluorescence microscopy. Complement deposition was localized to the central lobular areas and was associated with hepatocyte and sinusoidal endothelial cells in WT mice. C3 deposition was reduced in mice treated with 0.08 mg CR2-Crry and was absent in mice treated with 0.25 mg CR2-Crry and in C3–/– mice. Representative images, n = 3. Images are representative of 3 experiments. Scale bars: 75 μm.