Skip to main content
. 2009 Jul 20;119(8):2304–2316. doi: 10.1172/JCI38289

Figure 8. Effect of C3 deficiency and complement inhibition on hepatic and serum levels of TNF-α and IL-6 following IRI and PHx.

Figure 8

Mice were treated with normal saline or CR2-Crry at a dose of either 0.25 mg or 0.08 mg immediately after surgery. C3–/– mice received no treatment. (A) Serum TNF-α levels 6 hours after PHx. (B) Serum IL-6 levels 6 hours after PHx. (C) Serum TNF-α levels 48 hours after PHx. (D) Serum IL-6 levels 48 hours after PHx. (E) Hepatic TNF-α levels 3 hours after PHx. (F) Hepatic IL-6 levels 3 hours after PHx. Low-dose CR2-Crry treatment was associated with high hepatic levels of IL-6 and TNF-α early after PHx relative to other groups and lower relative serum cytokine levels by 48 hours after PHx. #P < 0.05, ##P < 0.01 versus WT group; *P < 0.05, **P < 0.01 versus WT group (similar to WT normal saline group); ††P < 0.01 versus CR2-Crry 0.25 mg and C3–/– groups. Results are expressed as mean ± SD; n = 6 for all groups.