Table 2.
Biodistribution of [99mTc(CO)3-DTMA-(X)-BBN(7–14)NH2]+ conjugates in CF-1 normal mice at 1 h p.i. (n=5, % ID/g±S.D.)
| Tissue/organ | X=β-ala | X=GGG | X=GSG | X=SSS |
|---|---|---|---|---|
| Bladder | 0.65 (0.38) | 1.17 (0.81) | 1.41 (1.58) | 3.52 (2.77) |
| Heart | 0.15 (0.04) | 1.86 (029) | 0.40 (0.21) | 1.58 (0.15) |
| Lungs | 0.26 (0.04) | 0.46 (0.10) | 0.49 (0.27) | 2.55 (0.28) |
| Liver | 7.48 (0.87) | 9.52 (1.29) | 5.49 (2.12) | 6.38 (0.96) |
| Kidney | 3.49 (0.65) | 2.30 (0.50) | 3.39 (2.0) | 6.37 (0.30) |
| Spleen | 1.16 (0.17) | 0.47 (0.08) | 1.09 (0.54) | 0.97 (0.12) |
| Stomach | 1.03 (0.50) | 2.27 (1.23) | 0.96 (0.42) | 0.82 (0.26) |
| Small intestine | 20.52 (2.73) | 16.97 (2.93) | 5.92 (1.85) | 5.07 (0.79) |
| Large Intestine | 3.37 (1.00) | 9.14 (2.55) | 4.07 (0.91) | 1.81 (0.50) |
| Muscle | 0.12 (0.06) | 0.20 (0.07) | 0.11 (0.07) | 0.43 (0.06) |
| Bone | 0.30 (0.16) | 0.19 (0.04) | 0.23 (0.08) | 0.80 (0.22) |
| Brain | 0.03 (0.01) | 0.02 (0.01) | 0.03 (0.02) | 0.21 (0.15) |
| Pancreas | 19.43 (4.31) | 10.36 (0.90) | 15.48 (5.25) | 8.00 (0.88) |
| Blood | 0.22 (0.02) | 0.17 (0.04) | 0.32 (0.13) | 2.73 (0.40) |
| Urine | 41.37 (2.77) | 38.31 (23.68) | 63.75 (13.03) | 57.69 (4.04) |