Table 3.
Biodistribution of [99mTc(CO)3-DTMA-(β-Ala)-BBN(7–14)NH2]+ conjugate in PC-3 tumorbearing mice at 1, 4 and 24 h p.i. (n=5,%ID/g±S.D.)
| Tissue/organ | 1 h | 4 h | 24 h |
|---|---|---|---|
| Bladder | 0.94 (1.25) | 0.29 (0.22) | 0.00 (0.00) |
| Heart | 0.28 (0.04) | 0.18 (0.02) | 0.16 (0.31) |
| Lungs | 0.56 (0.07) | 0.29 (0.07) | 0.10 (0.12) |
| Liver | 5.38 (1.30) | 1.99 (0.40) | 0.64 (0.19) |
| Kidney | 3.05 (0.51) | 1.92 (0.76) | 0.48 (0.20) |
| Spleen | 0.38 (0.10) | 0.43 (0.19) | 0.26 (0.27) |
| Stomach | 0.93 (0.65) | 0.39 (0.19) | 1.96 (4.08) |
| Small intestine | 25.36 (4.73) | 2.19 (1.00) | 0.85 (0.93) |
| Large intestine | 1.75 (0.63) | 50.63 (27.45) | 2.08 (3.62) |
| Muscle | 0.16 (0.03) | 0.06 (0.01) | 0.02 (0.03) |
| Bone | 0.24 (0.07) | 0.13 (0.06) | 0.00 (0.00) |
| Brain | 0.03 (0.00) | 0.03 (0.01) | 0.00 (0.01) |
| Pancreas | 8.20 (2.38) | 8.27 (2.47) | 4.12 (1.23) |
| Tumor 1 | 0.92 (0.17) | 0.47 (0.11) | 0.11 (0.07) |
| Tumor 2 | 0.98 (0.12) | 0.56 (0.09) | 0.14 (0.07) |
| Blood | 0.73 (0.60) | 0.37 (0.24) | 0.11 (0.04) |
| Urine | 50.50 (3.07) | 57.64 (10.44) | 94.01 (5.04) |