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Cyclin D1 and p21 expressions in colorectal cancer.
A. Heterogeneous nuclear cyclin D1 expression in carcinoma (arrowheads) and very weak cyclin D1 expression in normal colonic mucosa (empty arrows). B. Strong and diffuse nuclear cyclin D1 overexpression in carcinoma (arrow). C. Loss of nuclear p21 in carcinoma (empty arrows). Inflammatory cells serve as internal positive control (solid arrowhead). D. Intact nuclear p21 expression in carcinoma cells (arrows).
