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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: J Org Chem. 2008 Oct 21;73(22):8780–8784. doi: 10.1021/jo8015067

Table 2.

RuO2-NaIO4 Mediated Oxidation.

entry ynamides α-keto-imidesa yield [%]b
1 graphic file with name nihms127629t1.jpg 11 graphic file with name nihms127629t2.jpg 17 91
2 graphic file with name nihms127629t3.jpg 12 graphic file with name nihms127629t4.jpg 18 77
3 graphic file with name nihms127629t5.jpg 13 graphic file with name nihms127629t6.jpg 19 95
4 graphic file with name nihms127629t7.jpg 14 graphic file with name nihms127629t8.jpg 20 71
5 graphic file with name nihms127629t9.jpg 15 graphic file with name nihms127629t10.jpg 21 79
6 graphic file with name nihms127629t11.jpg 16 graphic file with name nihms127629t12.jpg 22 99
a

5 mol% RuO2•H2O, 3 equiv NaIO4, CH2Cl2/CH3CN/H2O, rt, 4 h.

b

Isolated yields.