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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Proteins. 2009 May 15;75(3):556–568. doi: 10.1002/prot.22271

Fig. 2. Effect of PR inhibitors on ΔTm values for PR, PRD25N and PRD29N.

Fig. 2

The bar graphs (ΔTm) represent the increase in Tm observed on binding of each of the inhibitors to each of the PR constructs (PR, red; PRD25N, orange; PRD29N, dark yellow). Numbers under the bar graphs are the ratios of ΔTm(PR)/ΔTm(PRD25N) (orange) and ΔTm(PR)/ΔTm(PRD29N) (dark yellow) for each of the inhibitors; large numbers for this ratio indicate that the mutated residue makes a large contribution to inhibitor binding. Data for PR and PRD25N in the absence of inhibitor and in the presence of a twofold molar excess of DRV or RPB are taken from ref. 17.