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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Proteins. 2009 May 15;75(3):556–568. doi: 10.1002/prot.22271

Fig. 7. Predicted molecular interactions of pepsin with APV at its active site based on structure overlays of HIV-1 PR/APV (1HPV), HIV-1 PR/Ac-PEP (5HVP) and pepsin/pepstatin A (1PSO) crystal complexes.

Fig. 7

Essential aspartyl residues, Asp25 and Asp29 of HIV-1 PR are indicated. The catalytic Asp32 and Asp215 residues of pepsin, and Ser219 and Ser36 residues that are in equivalent positions to that of Asp29 and Asp29′ of PR are also indicated. Distances are indicated in angstroms.