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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Epilepsia. 2007 Nov 21;49(3):488–499. doi: 10.1111/j.1528-1167.2007.01413.x

Figure 1. Spontaneous Activity in Q54 hippocampal slices.

Figure 1

Extracellular recordings from CA1 or CA3 pyramidal cell layers in the hippocampus show spontaneous activity in some CA1 (33%, n = 12) and CA3 (37.5%, n = 8) pyramidal cell layer of Q54 slices, but was not found in CA1 (n = 8) or CA3 (n = 6) pyramidal cell layer of WT slices from Q54 and WT mice aged 8–10 weeks. A) extracellular trace from CA1 of WT slice in nACSF; B) extracellular trace from CA1 of Q54 slice in nACSF showing spontaneous activity (scale = 0.5mV, 10s); C) expanded segment (indicated by bar) of extracellular Q54 trace shown in Fig. 1B. (scale = 0.5mV, 0.2s). D) Power analysis of recorded signals supports a significant increase in spontaneous activity in Q54 mice. Error bars represent SD.