Figure 4.
Electrostatics of binding: (a) The electrostatic potential surface of PFA1 with bound Aβ(1–8)peptide, (b) with bound pyro-Glu3-peptide and (c) Ror2(518–525). Blue represents positive charge, red indicates negative charge, and the uncharged portions are shown in white. Each of the peptides is drawn with carbon (yellow), nitrogen (blue), and oxygen (red). The numbering scheme is that of Aβ(1–8) WT.