Table 3.
Distribution of aspirin-related genotypes among Hodgkin lymphoma cases and controls by age group, and odds ratios (ORs) and 95% confidence intervals (CIs) for associations with risk of Hodgkin lymphoma by age group
| Ages 15–49 years | Ages 50–79 years | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (N=379) |
Controls (N=262) |
Cases (N=94) |
Controls (N=111) |
||||||||||||
| Gene | refSNP ID | Genotype | N | (%) | N | (%) | OR* | (95% CI) | N | (%) | N | (%) | OR | (95% CI) | Pheterogeneity |
| NFKB1 (nuclear factor kappa-B, subunit 1) | |||||||||||||||
| rs1585215 | AA | 94 | (27%) | 101 | (41%) | 1.0 | referent | 17 | (19%) | 50 | (46%) | 1.0 | referent | ||
| AG | 195 | (55%) | 120 | (49%) | 1.8 | (1.2, 2.6) | 55 | (60%) | 49 | (45%) | 3.7 | (1.8, 7.6) | |||
| GG | 63 | (18%) | 23 | (9%) | 3.0 | (1.7, 5.3) | 19 | (21%) | 10 | (9%) | 5.4 | (2.0, 14.5) | 0.25 | ||
| Ptrend=2.8×10−5 | Ptrend=1.7×10−4 | ||||||||||||||
| rs1599961 | GG | 141 | (39%) | 87 | (34%) | 1.0 | referent | 29 | (31%) | 41 | (37%) | 1.0 | referent | ||
| GA | 173 | (48%) | 122 | (47%) | 0.9 | (0.6, 1.3) | 48 | (51%) | 53 | (48%) | 1.3 | (0.6, 3.2) | |||
| AA | 49 | (13%) | 48 | (19%) | 0.6 | (0.4, 1.0) | 17 | (18%) | 16 | (15%) | 1.3 | (0.7, 2.5) | 0.26 | ||
| Ptrend=0.09 | Ptrend=0.44 | ||||||||||||||
| rs1609993 | CC | 305 | (82%) | 227 | (87%) | 1.0 | referent | 83 | (88%) | 91 | (82%) | 1.0 | referent | ||
| CT | 63 | (17%) | 32 | (12%) | 1.5 | (0.9, 2.3) | 10 | (11%) | 20 | (18%) | 0.6 | (0.3, 1.4) | 0.06 | ||
| TT | 2 | (1%) | 1 | (0%) | 1 | (1%) | 0 | (0%) | |||||||
| P=0.10 | P=0.26 | ||||||||||||||
| rs3774936 | AA | 168 | (47%) | 109 | (43%) | 1.0 | referent | 36 | (39%) | 52 | (48%) | 1.0 | referent | ||
| AT | 152 | (42%) | 120 | (47%) | 0.8 | (0.6, 1.2) | 42 | (45%) | 48 | (44%) | 1.2 | (0.7, 2.3) | |||
| TT | 41 | (11%) | 26 | (10%) | 1.0 | (0.6, 1.7) | 15 | (16%) | 9 | (8%) | 2.1 | (0.8, 5.5) | 0.31 | ||
| Ptrend=0.59 | Ptrend=0.16 | ||||||||||||||
| rs3774937 | TT | 162 | (45%) | 107 | (43%) | 1.0 | referent | 35 | (39%) | 50 | (46%) | 1.0 | referent | ||
| TC | 157 | (43%) | 117 | (47%) | 0.9 | (0.6, 1.2) | 40 | (44%) | 48 | (44%) | 1.2 | (0.6, 2.2) | |||
| CC | 43 | (12%) | 25 | (10%) | 1.1 | (0.6, 2.0) | 15 | (17%) | 10 | (9%) | 1.8 | (0.7, 4.8) | 0.58 | ||
| Ptrend=0.96 | Ptrend=0.24 | ||||||||||||||
| rs3774938 | AA | 139 | (39%) | 88 | (36%) | 1.0 | referent | 26 | (29%) | 40 | (37%) | 1.0 | referent | ||
| AG | 173 | (48%) | 117 | (48%) | 1.0 | (0.7, 1.4) | 48 | (53%) | 52 | (49%) | 1.5 | (0.8, 2.9) | |||
| GG | 48 | (13%) | 37 | (15%) | 0.8 | (0.5, 1.4) | 17 | (19%) | 15 | (14%) | 1.6 | (0.6, 3.9) | 0.38 | ||
| Ptrend=0.53 | Ptrend=0.25 | ||||||||||||||
| NFKBIA (nuclear factor kappa-B inhibitor alpha) | |||||||||||||||
| rs696 | GG | 112 | (30%) | 105 | (41%) | 1.0 | referent | 44 | (47%) | 48 | (44%) | 1.0 | referent | ||
| GA | 181 | (49%) | 110 | (43%) | 1.6 | (1.1, 2.3) | 34 | (37%) | 48 | (44%) | 0.8 | (0.4, 1.5) | |||
| AA | 77 | (21%) | 39 | (15%) | 2.0 | (1.2, 3.2) | 15 | (16%) | 14 | (13%) | 1.1 | (0.4, 2.6) | 0.11 | ||
| Ptrend=0.002 | Ptrend=0.83 | ||||||||||||||
| rs8904 | CC | 117 | (32%) | 103 | (41%) | 1.0 | referent | 45 | (48%) | 49 | (44%) | 1.0 | referent | ||
| CT | 176 | (48%) | 109 | (43%) | 1.4 | (1.0, 2.1) | 33 | (35%) | 49 | (44%) | 0.8 | (0.4, 1.4) | |||
| TT | 77 | (21%) | 42 | (17%) | 1.7 | (1.1, 2.7) | 15 | (16%) | 13 | (12%) | 1.1 | (0.5, 2.8) | 0.17 | ||
| Ptrend=0.02 | Ptrend=0.88 | ||||||||||||||
| rs1050851 | CC | 235 | (65%) | 144 | (57%) | 1.0 | referent | 61 | (67%) | 55 | (50%) | 1.0 | referent | ||
| CT | 111 | (30%) | 97 | (38%) | 0.7 | (0.5, 1.0) | 27 | (30%) | 46 | (42%) | 0.5 | (0.3, 1.0) | |||
| TT | 18 | (5%) | 11 | (4%) | 1.0 | (0.4, 2.1) | 3 | (3%) | 8 | (7%) | 0.3 | (0.1, 1.4) | 0.35 | ||
| Ptrend=0.13 | Ptrend=0.03 | ||||||||||||||
| rs1957106 | GG | 180 | (50%) | 135 | (54%) | 1.0 | referent | 53 | (59%) | 64 | (58%) | 1.0 | referent | ||
| GA | 147 | (40%) | 104 | (41%) | 1.0 | (0.7, 1.5) | 33 | (37%) | 40 | (36%) | 0.9 | (0.5, 1.7) | |||
| AA | 36 | (10%) | 12 | (5%) | 2.3 | (1.1, 4.6) | 4 | (4%) | 6 | (5%) | 0.8 | (0.2, 3.0) | 0.30 | ||
| Ptrend=0.08 | Ptrend=0.67 | ||||||||||||||
| IKKA/CHUK (inhibitor of nuclear factor kappa-B kinase alpha/conserved helix-loop-helix ubiquitous kinase) | |||||||||||||||
| rs2230804 | AA | 96 | (26%) | 60 | (24%) | 1.0 | referent | 22 | (24%) | 32 | (29%) | 1.0 | referent | ||
| AG | 184 | (50%) | 127 | (51%) | 0.9 | (0.6, 1.4) | 42 | (45%) | 44 | (40%) | 1.3 | (0.6, 2.6) | |||
| GG | 90 | (24%) | 62 | (25%) | 0.9 | (0.6, 1.5) | 29 | (31%) | 34 | (31%) | 1.1 | (0.5, 2.4) | 0.66 | ||
| Ptrend=0.72 | Ptrend=0.77 | ||||||||||||||
| PTGS2/COX2 (prostaglandin-endoperoxide synthase 2/cyclooxygenase-2) | |||||||||||||||
| rs5272 | AA | 352 | (97%) | 249 | (98%) | 1.0 | referent | 88 | (98%) | 109 | (99%) | 1.0 | referent | ||
| AG | 12 | (3%) | 5 | (2%) | 1.6 | (0.6, 4.7) | 2 | (2%) | 1 | (1%) | 1.1 | (0.1, 18.5) | 0.93 | ||
| GG | 0 | (0%) | 0 | (0%) | 0 | (0%) | 0 | (0%) | |||||||
| P=0.37 | P=0.96 | ||||||||||||||
| rs5277 | GG | 267 | (73%) | 192 | (74%) | 1.0 | referent | 65 | (71%) | 90 | (81%) | 1.0 | referent | ||
| GC | 96 | (26%) | 59 | (23%) | 1.1 | (0.8, 1.6) | 20 | (22%) | 19 | (17%) | 1.6 | (0.8, 3.3) | |||
| CC | 4 | (1%) | 7 | (3%) | 0.4 | (0.1, 1.4) | 6 | (7%) | 2 | (2%) | 4.0 | (0.6, 22.2) | 0.07 | ||
| Ptrend=0.80 | Ptrend=0.05 | ||||||||||||||
| rs20417 | GG | 224 | (62%) | 157 | (64%) | 1.0 | referent | 55 | (59%) | 74 | (69%) | 1.0 | referent | ||
| GC | 118 | (33%) | 83 | (34%) | 1.0 | (0.7, 1.5) | 33 | (35%) | 30 | (28%) | 1.6 | (0.9, 3.0) | |||
| CC | 19 | (5%) | 7 | (3%) | 2.0 | (0.8, 4.9) | 5 | (5%) | 3 | (3%) | 2.5 | (0.5, 12.5) | 0.54 | ||
| Ptrend=0.31 | Ptrend=0.08 | ||||||||||||||
| rs689466 | AA | 246 | (67%) | 174 | (69%) | 1.0 | referent | 68 | (75%) | 75 | (70%) | 1.0 | referent | ||
| AG | 103 | (28%) | 71 | (28%) | 1.1 | (0.8, 1.6) | 21 | (23%) | 28 | (26%) | 0.7 | (0.4, 1.5) | |||
| GG | 17 | (5%) | 9 | (4%) | 1.4 | (0.6, 3.2) | 2 | (2%) | 4 | (4%) | 0.6 | (0.1, 3.3) | 0.49 | ||
| Ptrend=0.43 | Ptrend=0.29 | ||||||||||||||
| CYP2C9 (cytochrome p450, family 2, subfamily C, polypeptide 9) | |||||||||||||||
| rs1057910 | AA | 319 | (86%) | 231 | (89%) | 1.0 | referent | 76 | (82%) | 93 | (84%) | 1.0 | referent | ||
| AC | 53 | (14%) | 28 | (11%) | 1.4 | (0.8, 2.2) | 17 | (18%) | 18 | (16%) | 1.2 | (0.6, 2.5) | 0.70 | ||
| CC | 0 | (0%) | 1 | (0%) | 0 | (0%) | 0 | (0%) | |||||||
| P=0.22 | P=0.67 | ||||||||||||||
| rs1799853 | CC | 271 | (72%) | 211 | (81%) | 1.0 | referent | 73 | (78%) | 82 | (75%) | 1.0 | referent | ||
| CT | 105 | (28%) | 43 | (17%) | 1.7 | (1.1, 2.5) | 21 | (22%) | 27 | (25%) | 0.9 | (0.4, 1.7) | 0.08 | ||
| TT | 0 | (0%) | 6 | (2%) | 0 | (0%) | 1 | (1%) | |||||||
| P=0.01 | P=0.67 | ||||||||||||||
| UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6) | |||||||||||||||
| rs1105879 | TT | 149 | (40%) | 101 | (41%) | 1.0 | referent | 36 | (39%) | 50 | (46%) | 1.0 | referent | ||
| TG | 183 | (49%) | 114 | (46%) | 1.1 | (0.8, 1.6) | 44 | (47%) | 49 | (45%) | 1.2 | (0.7, 2.3) | |||
| GG | 39 | (11%) | 33 | (13%) | 0.8 | (0.5, 1.4) | 13 | (14%) | 10 | (9%) | 1.7 | (0.6, 4.6) | 0.33 | ||
| Ptrend=0.72 | Ptrend=0.26 | ||||||||||||||
| rs2070959 | AA | 165 | (45%) | 115 | (44%) | 1.0 | referent | 37 | (40%) | 55 | (50%) | 1.0 | referent | ||
| AG | 169 | (46%) | 115 | (44%) | 1.0 | (0.7, 1.5) | 43 | (46%) | 45 | (41%) | 1.4 | (0.8, 2.7) | |||
| GG | 31 | (8%) | 29 | (11%) | 0.8 | (0.4, 1.3) | 13 | (14%) | 9 | (8%) | 2.1 | (0.8, 5.7) | 0.16 | ||
| Ptrend=0.57 | Ptrend=0.11 | ||||||||||||||
| LTC4S (leukotriene C4 synthase) | |||||||||||||||
| rs730012 | AA | 201 | (56%) | 147 | (58%) | 1.0 | referent | 46 | (51%) | 58 | (54%) | 1.0 | referent | ||
| AC | 135 | (38%) | 90 | (36%) | 1.1 | (0.8, 1.5) | 43 | (47%) | 42 | (39%) | 1.4 | (0.8, 2.6) | |||
| CC | 23 | (6%) | 16 | (6%) | 1.0 | (0.5, 2.0) | 2 | (2%) | 8 | (7%) | 0.3 | (0.1, 1.8) | 0.24 | ||
| Ptrend=0.82 | Ptrend=0.90 | ||||||||||||||
Missing data are excluded.
*
Adjusted for 5-year age group, sex, state, and race/ethnicity
P-values are not Bonferroni-adjusted.