Table 4.
Distribution of aspirin-related genotypes among Hodgkin lymphoma (HL) cases by tumor Epstein-Barr virus (EBV) status, and odds ratios (ORs) and 95% confidence intervals (CIs) for associations with risk of HL by EBV status, compared with all controls
| EBV-negative HL (N=290 cases) | EBV-positive HL (N=92 cases) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | refSNP ID | Genotype | N | (%) | OR* | (95% CI) | N | (%) | OR* | (95% CI) | Pheterogeneity |
| NFKB1(nuclear factor kappa-B, subunit 1) | |||||||||||
| rs1585215 | AA | 69 | (26%) | 1.0 | referent | 19 | (22%) | 1.0 | referent | ||
| AG | 153 | (57%) | 2.0 | (1.4, 3.0) | 53 | (61%) | 2.6 | (1.4, 4.7) | |||
| GG | 48 | (18%) | 3.2 | (1.9, 5.6) | 15 | (17%) | 3.3 | (1.4, 7.4) | 0.77 | ||
| Ptrend=3.0×10−6 | Ptrend=8.1×10−4 | ||||||||||
| rs1599961 | GG | 104 | (37%) | 1.0 | referent | 35 | (39%) | 1.0 | referent | ||
| GA | 136 | (49%) | 1.0 | (0.7, 1.4) | 42 | (47%) | 0.9 | (0.5, 1.5) | |||
| AA | 40 | (14%) | 0.8 | (0.5, 1.2) | 12 | (13%) | 0.6 | (0.3, 1.3) | 0.55 | ||
| Ptrend=0.31 | Ptrend=0.25 | ||||||||||
| rs1609993 | CC | 240 | (84%) | 1.0 | referent | 71 | (79%) | 1.0 | referent | ||
| CT | 43 | (15%) | 1.1 | (0.7, 1.8) | 18 | (20%) | 1.7 | (0.9, 3.1) | 0.19 | ||
| TT | 2 | (1%) | 1 | (1%) | |||||||
| P=0.55 | P=0.09 | ||||||||||
| rs3774936 | AA | 125 | (45%) | 1.0 | referent | 40 | (45%) | 1.0 | referent | ||
| AT | 118 | (43%) | 0.9 | (0.6, 1.2) | 39 | (44%) | 0.9 | (0.6, 1.6) | |||
| TT | 33 | (12%) | 1.2 | (0.7, 2.0) | 10 | (11%) | 1.0 | (0.4, 2.3) | 0.68 | ||
| Ptrend=0.97 | Ptrend=0.93 | ||||||||||
| rs3774937 | TT | 120 | (44%) | 1.0 | referent | 40 | (45%) | 1.0 | referent | ||
| TC | 121 | (44%) | 0.9 | (0.7, 1.3) | 39 | (44%) | 1.0 | (0.6, 1.6) | |||
| CC | 34 | (12%) | 1.2 | (0.7, 2.1) | 10 | (11%) | 1.0 | (0.4, 2.3) | 0.63 | ||
| Ptrend=0.72 | Ptrend=0.93 | ||||||||||
| rs3774938 | AA | 101 | (36%) | 1.0 | referent | 33 | (38%) | 1.0 | referent | ||
| AG | 136 | (49%) | 1.1 | (0.7, 1.5) | 42 | (49%) | 1.0 | (0.6, 1.7) | |||
| GG | 40 | (14%) | 1.0 | (0.6, 1.6) | 11 | (13%) | 0.8 | (0.3, 1.7) | 0.40 | ||
| Ptrend=0.93 | Ptrend=0.55 | ||||||||||
| NFKBIA (nuclear factor kappa-B inhibitor alpha) | |||||||||||
| rs696 | GG | 94 | (33%) | 1.0 | referent | 32 | (36%) | 1.0 | referent | ||
| GA | 131 | (46%) | 1.3 | (0.9, 1.9) | 39 | (44%) | 1.2 | (0.7, 2.1) | |||
| AA | 58 | (20%) | 1.7 | (1.1, 2.7) | 18 | (20%) | 1.6 | (0.8, 3.2) | 0.99 | ||
| Ptrend=0.02 | Ptrend=0.16 | ||||||||||
| rs8904 | CC | 97 | (34%) | 1.0 | referent | 33 | (37%) | 1.0 | referent | ||
| CT | 128 | (45%) | 1.2 | (0.9, 1.7) | 39 | (43%) | 1.2 | (0.7, 2.0) | |||
| TT | 59 | (21%) | 1.5 | (1.0, 2.5) | 18 | (20%) | 1.5 | (0.8, 3.0) | 0.96 | ||
| Ptrend=0.06 | Ptrend=0.23 | ||||||||||
| rs1050851 | CC | 186 | (66%) | 1.0 | referent | 58 | (66%) | 1.0 | referent | ||
| CT | 81 | (29%) | 0.6 | (0.4, 0.9) | 27 | (31%) | 0.7 | (0.4, 1.2) | |||
| TT | 15 | (5%) | 0.9 | (0.4, 1.8) | 3 | (3%) | 0.6 | (0.2, 2.3) | 0.63 | ||
| Ptrend=0.03 | Ptrend=0.14 | ||||||||||
| rs1957106 | GG | 141 | (51%) | 1.0 | referent | 42 | (49%) | 1.0 | referent | ||
| GA | 113 | (41%) | 1.0 | (0.7, 1.4) | 34 | (40%) | 1.2 | (0.7, 2.1) | |||
| AA | 24 | (9%) | 1.7 | (0.8, 3.2) | 10 | (12%) | 2.7 | (1.1, 6.7) | 0.34 | ||
| Ptrend=0.31 | Ptrend=0.06 | ||||||||||
| IKKA/CHUK (inhibitor of nuclear factor kappa-B kinase alpha/conserved helix-loop-helix ubiquitous kinase) | |||||||||||
| rs2230804 | AA | 70 | (25%) | 1.0 | referent | 24 | (27%) | 1.0 | referent | ||
| AG | 139 | (49%) | 1.0 | (0.7, 1.6) | 42 | (47%) | 1.0 | (0.6, 1.8) | |||
| GG | 76 | (27%) | 1.0 | (0.7, 1.6) | 23 | (26%) | 0.9 | (0.5, 1.8) | 0.84 | ||
| Ptrend=0.86 | Ptrend=0.79 | ||||||||||
| PTGS2/COX2 (prostaglandin-endoperoxide synthase 2/cyclooxygenase-2) | |||||||||||
| rs5272 | AA | 269 | (97%) | 1.0 | referent | 84 | (95%) | 1.0 | referent | ||
| AG | 9 | (3%) | 1.8 | (0.6, 5.3) | 4 | (5%) | 2.1 | (0.5, 8.0) | 0.66 | ||
| GG | 0 | (0%) | 0 | (0%) | |||||||
| P=0.29 | P=0.29 | ||||||||||
| rs5277 | GG | 212 | (75%) | 1.0 | referent | 62 | (70%) | 1.0 | referent | ||
| GC | 70 | (25%) | 1.1 | (0.8, 1.7) | 22 | (25%) | 1.2 | (0.7, 2.2) | |||
| CC | 2 | (1%) | 0.3 | (0.1, 1.3) | 4 | (5%) | 2.0 | (0.6, 7.0) | 0.12 | ||
| Ptrend=0.74 | Ptrend=0.25 | ||||||||||
| rs20417 | GG | 170 | (61%) | 1.0 | referent | 49 | (56%) | 1.0 | referent | ||
| GC | 93 | (33%) | 1.2 | (0.9, 1.7) | 35 | (40%) | 1.5 | (0.9, 2.6) | |||
| CC | 16 | (6%) | 2.5 | (1.0, 5.8) | 3 | (3%) | 1.3 | (0.3, 5.4) | 0.53 | ||
| Ptrend=0.05 | Ptrend=0.13 | ||||||||||
| rs689466 | AA | 185 | (67%) | 1.0 | referent | 71 | (79%) | 1.0 | referent | ||
| AG | 81 | (29%) | 1.1 | (0.7, 1.5) | 14 | (16%) | 0.5 | (0.3, 0.9) | |||
| GG | 12 | (4%) | 1.2 | (0.5, 2.7) | 5 | (6%) | 1.2 | (0.4, 3.7) | 0.08 | ||
| Ptrend=0.61 | Ptrend=0.20 | ||||||||||
| CYP2C9 (cytochrome p450, family 2, subfamily C, polypeptide 9) | |||||||||||
| rs1057910 | AA | 240 | (84%) | 1.0 | referent | 73 | (83%) | 1.0 | referent | ||
| AC | 46 | (16%) | 1.4 | (0.9, 2.2) | 15 | (17%) | 1.5 | (0.8, 3.0) | 0.71 | ||
| CC | 0 | (0%) | 0 | (0%) | |||||||
| P=0.15 | P=0.19 | ||||||||||
| rs1799853 | CC | 209 | (73%) | 1.0 | referent | 65 | (71%) | 1.0 | referent | ||
| CT | 79 | (27%) | 1.5 | (1.0, 2.2) | 26 | (29%) | 1.5 | (0.9, 2.6) | 0.74 | ||
| TT | 0 | (0%) | 0 | (0%) | |||||||
| P=0.03 | P=0.15 | ||||||||||
| UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6) | |||||||||||
| rs1105879 | TT | 109 | (38%) | 1.0 | referent | 39 | (43%) | 1.0 | referent | ||
| TG | 142 | (50%) | 1.2 | (0.8, 1.6) | 42 | (46%) | 1.0 | (0.6, 1.7) | |||
| GG | 34 | (12%) | 1.1 | (0.7, 1.9) | 10 | (11%) | 0.9 | (0.4, 2.0) | 0.49 | ||
| Ptrend=0.49 | Ptrend=0.88 | ||||||||||
| rs2070959 | AA | 123 | (44%) | 1.0 | referent | 41 | (45%) | 1.0 | referent | ||
| AG | 129 | (46%) | 1.1 | (0.8, 1.5) | 42 | (46%) | 1.1 | (0.7, 1.9) | |||
| GG | 30 | (11%) | 1.1 | (0.7, 2.0) | 8 | (9%) | 0.9 | (0.4, 2.1) | 0.78 | ||
| Ptrend=0.58 | Ptrend=0.94 | ||||||||||
| LTC4S (leukotriene C4 synthase) | |||||||||||
| rs730012 | AA | 139 | (50%) | 1.0 | referent | 49 | (57%) | 1.0 | referent | ||
| AC | 119 | (43%) | 1.4 | (1.0, 1.9) | 33 | (38%) | 1.0 | (0.6, 1.7) | |||
| CC | 20 | (7%) | 1.2 | (0.6, 2.3) | 4 | (5%) | 0.7 | (0.2, 2.2) | 0.39 | ||
| Ptrend=0.14 | Ptrend=0.66 | ||||||||||
Missing data are excluded.
*
Adjusted for 5-year age group, sex, state, and race/ethnicity
P-values are not Bonferroni-adjusted.