TABLE 1.

LUNG ABNORMALITIES IN Itgb6^−/− MICE DUE TO LACK OF TGF-β

Process	Description	Reference
Inflammation	Activated lymphocytes around airways and vessels; similar to lesions in Tgfb1−/− mice	(14)
Fibrosis	Protection from bleomycin-induced lung fibrosis	(9)
Acute lung injury	Reduced capillary leak after bleomycin-induced lung injury	(18)
Emphysema	Late onset emphysema due to excess MMP12 production by alveolar macrophages	(16)
EMT	Alveolar epithelial type 2 cells cultured on fibronectin undergo EMT due to αvβ6-mediated TGF-β activation	(19)
Alveolar macrophage function	αvβ6-mediated TGF-β activation inhibits alveolar macrophage functionality; inhibition can be overridden by Toll-like receptor signaling	(20)
Surfactant homeostasis	αvβ6-mediated TGF-β activation is required for normal surfactant homeostasis, probably via effects on alveolar macrophage-mediated surfactant catabolism	(23)

Definition of abbreviations: EMT, epithelial-mesenchymal transition; TGF-β, transforming growth factor-β.