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A: Wild type Adenovirus encodes for viral E1A protein that can bind to and inactivate cellular pRb protein. Inactivation of Rb releases E2F transcriptional factor driving the host cell into a proliferative phase, facilitating viral replication. B; Adenoviruses with a mutant E1A, can not inactivate cellular Rb, and can hence replicate only in cells with a mutant p16/pRb pathway.
