Figure 3.

Measurements of serum OVA-specific immunoglobulin (Ig)E and IgG1 levels in CD38^−/− mice after OVA sensitization and challenge, and of the Th2 cytokines IL-4, -5, and -13 from peribronchial lymph nodes harvested from CD38^−/− and BL6 mice. (A) Levels of serum OVA-specific IgE and IgG1 in challenged (C) or sensitized and challenged (S/C) mice. (B) Levels of IL-4, IL-5, and IL-13 in the supernatants of cell suspensions from peribronchial lymph node that were obtained from challenged (C) or sensitized and challenged (S/C) BL6 and CD38^−/− mice, and cultured for 4 days in the presence of 100 μg/ml OVA at 37°C. *P < 0.05 for BL6 S/C compared with CD38^−/− S/C.