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. 2008 Oct 17;40(4):433–442. doi: 10.1165/rcmb.2007-0392OC

Figure 4.

Figure 4.

Reciprocal bone marrow swaps between WT-BL6 and CD38−/− mice result in the restoration of the inflammatory phenotype to the BM-donor phenotype, but not of the mucus secretion: Reconstitution of lethally irradiated CD38−/− mice with BL6 bone marrow (BL6 > CD38) restores airway inflammation after OVA sensitization and challenge, whereas reconstitution of BL6 mice with CD38−/− bone marrow suppresses it. (A) Leukocyte numbers in the BAL of irradiated BL6 and CD38−/− mice, reconstituted either with parental or with reciprocal bone marrow, after ovalbumin sensitization and challenge (S/C). (B) H&E-stained lung sections from naïve sensitized and challenged (S/C) BL6 and CD38−/− mice, either intact or reconstituted with reciprocal bone marrow swaps. (C) Number of PAS-positive cells/mm of basal membrane (BM) identified from lung sections obtained from sensitized and challenged (S/C) BL6 and CD38−/− mice, either intact or reconstituted with reciprocal bone marrow. *P < 0.05.