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. 2009 Jan 8;179(7):572–578. doi: 10.1164/rccm.200807-1097OC

TABLE 5.

EFFECTS OF BLACK CARBON AND PM2.5 ON LINE-1 METHYLATION IN MODELS INCLUDING SHORT-TERM (4-h) AND MID-TERM (7-d) MOVING AVERAGES OF AMBIENT POLLUTANT LEVEL

Effects on LINE-1 Methylation
Coeff* (95% CI) P Value
Black carbon (4-h + 7-d model)
 4-h mean −0.05 (−0.11 to 0.02) 0.16
 7-d mean −0.09 (−0.16 to −0.02) 0.008
PM2.5 (4-h + 7-d model)
 4-h mean −0.04 (−0.11 to 0.03) 0.24
 7-d mean −0.11 (−0.18 to −0.05) 0.001

For definition of abbreviations, see Table 4.

*

Standardized correlation coefficients, expressing the fraction of a standard deviation change in DNA methylation associated with a standard deviation change in pollutant level, adjusted for age, body mass index, cigarette smoking (never, former, current), pack-years, statin use, fasting blood glucose, diabetes mellitus, percent lymphocytes and neutrophils in differential blood count, day of the week, season, and outdoor temperature.