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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Cancer Cell. 2008 Aug 12;14(2):180–192. doi: 10.1016/j.ccr.2008.06.014

Figure 8. Tolerance to mutation in the p110α affinity pocket.

Figure 8

A: Colony size distributions for 384 colony arrays of the indicated p110α mutant libraries, grown in the YRP1 strain on SD −URA +Galactose media as described in Fig. 4A.

B: Tolerance to mutation as calculated by Σ(1-x)2 from the distributions in Fig. 8A, where x equals relative colony size. These values were converted into heat map values and are shown on the p110α crystal structure (PDB code 2RD0) with the PI3K inhibitor PIK-90 from the p110γ co-crystal structure (PDB code 2CHX) overlaid by structural alignment.