Results of main effects analysis (green) and shared effect analysis (yellow) of Simple Sarcasm (SSR) condition score, superimposed on sagittal (x = 28, x = 46), coronal (y = −16), and axial (z = 18, z = −22) slices of an averaged template brain (SPM5: t1.nii). Green colored areas represent regions where atrophy significantly correlated with poorer performance on the SSR task, controlling for sincere score, MMSE, age, sex, and TIV. Yellow colored areas represent regions remaining significant when diagnostic group membership was added into the design matrix, indicating regions that showed a significant relationship to sarcasm interpretation in more than one diagnostic group. Results are shown at a corrected level of significance (pFWE < 0.05) using the T-score range shown at the bottom right.