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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Curr Opin Immunol. 2009 Mar 21;21(2):224–232. doi: 10.1016/j.coi.2009.02.010

Figure 1. Glucocorticoids exert negative effects on adoptively transferred T cells through both nongenomic and genomic mechanisms.

Figure 1

The non ligated glucocorticoid receptor (GR) is associated with the T cell receptor signaling complexes containing Fyn and Lck. Immediately upon binding of the GR to glucocorticoid (GC), these multiprotein complexes are disrupted leading to failure of downstream signaling after engagement of the TCR by antigen. Binding of GC to the GR in the cytoplasm also leads to translocation of the bound receptor to the nucleus and regulation of a number of glucocorticoid responsive genes, including repression of proinflammatory genes such as IL-2, and activation of immunosuppressive genes such as MAPK phosphatase-1, and interleukin 10.