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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Adv Drug Deliv Rev. 2008 Apr 3;60(10):1153–1166. doi: 10.1016/j.addr.2008.03.005

Figure 5.

Figure 5

Intravital microscopy of the cremaster muscle in mice following intravascular injection of cationic microbubbles bearing YOYO-1-labeled plasmid. (A) Cremaster microcirculation 1 min after IV injection of microbubbles illustrating stable conjugation of plasmid to microbubbles during microvascular transit. All microbubbles in the field transited unimpeded. (B) Microvessel rupture and peri-vascular hemorrhage with fluorescent DNA deposition at a site of microbubble destruction. (C,D) Deposition of fluorescent plasmid DNA in the perivascular tissue of cremasteric venules following US-mediated destruction of microbubbles without vessel rupture. Scale bar - 20 μm. (Reproduced with permission from ref. [110], Copyright, 2003, Elsevier).