Skip to main content
. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Bioorg Med Chem. 2007 Nov 26;16(4):2114–2130. doi: 10.1016/j.bmc.2007.10.081

Figure 1.

Figure 1

Structure of inhibitors used in this study. Greek letters refer to atom positioning and are consistent for all compounds. A) ketone form of the inhibitor. B) gem-diol or hydrated form of the inhibitor. C) Putative intramolecular hydrogen bond between the gem-diol and sulfur atom β to the ketone/gem-diol. D) Putative intramolecular hydrogen bond between the gem-diol and the sulfoxide moiety β to the ketone/gem-diol (the sulfone analog is hypothesized to form a similar 6-membered ring upon formation of the putative hydrogen bond).