Table 2.

Dependence of FAAH IC₅₀ upon sulfur oxidation state^a

Rb	Thioether			Sulfoxide			Sulfone			TFDKd
	N°c	5 min	15 min	N°	5 min	15 min	N°	5 min	15 min	N°	5 min	15 min
4	1	>40,000	>40,000	6	>40,000	>40,000		N.D.e	N.D.		N.D.	N.D.
6	2	1950±250	2500±190	7	>40,000	>40,000	11	>40,000	>40,000		N.D.	N.D.
8	3	230±20	300±30	8	6500±650	13,900±900	12	14,800±700	22,500±1100	15	1250±110	1800±130
10	4	120±10	170±20	9	760±50	1350±90	13	2200±200	3000±230		N.D.	N.D.
12	5	84±7.5	89±7.8	10	440±50	600±40	14	250±10	280±30		N.D.	N.D.

^aAll values are given as the average ± the standard deviation of 3 replicates in units of nM. Incubation of enzyme and inhibitor was performed for either 5 min or 15 min before addition of substrate as described in the Experimental.

^bR refers to the number of carbon atoms in the alkyl chain as shown in Figure 1.

^cIndividual compound numbers.

^d1,1,1-trifluorododecan-2-one.

^eN.D. indicates that value was not determined.