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Esterase and FAAH inhibition by benzila
| hCE-1 | hCE-2 | Porcine Esterase | Rabbit Esterase | FAAH | |||||
|---|---|---|---|---|---|---|---|---|---|
| 5 min | 15 min | 5 min | 15 min | 5 min | 15 min | 5 min | 15 min | 5 min | 15 min |
| 27±1.0 | 43±1.3 | 38±1.0 | 44±1.1 | 370±26 | 830±34 | 19±2.0 | 29±1.7 | >40,000 | >40,000 |
All values are given as the average IC50 ± the standard deviation of 3 replicates in units of nM. Incubation of enzyme and inhibitor was performed for either 5 min or 15 min before addition of substrate as described in the Experimental.
