Table 4.

Bimolecular rate constant (k_i) for inhibitor binding to esterases^a

R	Thioether			Sulfoxide			Sulfone			TFDKb
	N°c	ki	SD	N	ki	SD	N	ki	SD	N	ki	SD
Porcine Esterase
4	1	1.53×107	3.0×105	6	1.30×106	5.0×104		N.D.d	N.D.		N.D.c	N.D.
6	2	1.05×107	7.5×105	7	5.20×105	3.5×104	11	2.67×105	2.4×104		N.D.	N.D.
8	3	2.53×107	1.6×106	8	5.72×106	3.2×105	12	5.76×105	3.5×104	15	2.07×107	1.2×106
10	4	9.80×108	1.4×107	9	5.44×108	1.8×107	13	5.88×108	5.6×107		N.D.	N.D.
12	5	1.86×107	3.8×105	10	1.97×107	1.2×106	14	4.10×106	1.3×105		N.D.	N.D.
hCE1
8	3	1.02×107	6.2×105	8	6.74×106	1.7×105	12	2.47×107	7.5×105	15	6.67×106	2.0×105
hCE2
8	3	3.48×107	1.9×106	8	1.08×107	7.8×105	12	4.27×106	1.4×105	15	2.29×107	1.2×106
Rabbit Esterase
8	3	1.71×107	6.1×105	8	5.12×106	1.7×105	12	4.04×106	1.2×105	15	4.39×106	2.2×105

^aAll values are given as the average ± the standard deviation of 3 replicates in units of M⁻¹min⁻¹.

^b1,1,1-trifluorododecan-2-one

^cIndividual compound numbers.

^dN.D. indicates that value was not measured.