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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Acc Chem Res. 2007 Jun 14;40(7):475–483. doi: 10.1021/ar700052v

FIGURE 1.

FIGURE 1

Proposed extradiol dioxygenase mechanism. R = -CH2COOH (HPCA) or –NO2 (4NC) for the studies described here. Single hydroxyl deprotonation during binding results in a bound monoanion in the case of HPCA (shown) and a bound dianion for 4NC.