Table 1. Parameter values used in the simulation.
Parameter | Steady statea | Recovery phaseb | Referencesc |
---|---|---|---|
r 1 | 0.03 [/d] | Variable | Bradford et al (1997); Sudo et al (2000) |
r 2 | 0.8 [/d] | Variable | Passegué et al (2005) |
r 3 | 0.55 [/d] | Variable | Passegué et al (2005) |
r 4 | 1.9 [/d] | Passegué et al (2005) | |
r 5 | 2.5 [/d] | Passegué et al (2005) | |
P 21 | 0.5−P22 | Variable | |
P 22 | 0.462 | Variable | |
P 23 | 1−P21−P22 | ||
P 33 | 0.480 | ||
P 34 | 0.5 (1−P33) | ||
P 44 | 0.457 | Variable | |
P 45 | 0.75 (1−P44) | Spangrude and Johnson (1990) | |
P 55 | 0.320 |
Values for the unexposed steady state.
Values for 3 Gy-exposed mice. Parameters modulated in response to haematopoietic demands are denoted as ‘variable’.
References for the values or the relational expressions. For details, see the Supplementary material.