Table 1. PARP-1 expression, activity and genotype in a panel of different cancer cell lines.
| Cell line | (CA)n genotype | T2444C genotype | PARP-1 expression | PARP activity |
|---|---|---|---|---|
| Pre B697 | SS | T/C | High | High |
| NGP | — | T/T | Medium | High |
| TR14 | SS | T/T | Medium | High |
| NB1691 | SS | T/T | High | Medium |
| SK-N-BE2C | SL | T/T | High | Medium |
| Nalm-6 | SS | T/T | High | Medium |
| K562 | SS | T/T | Medium | Medium |
| HL-60 | SL | T/T | Medium | Medium |
| Molt-4 | SL | T/T | Medium | Medium |
| MCF-7 | SS | T/T | Medium | Medium |
| Raji | LL | T/T | Medium | Medium |
| LoVo | LL | T/C | Medium | Medium |
| LS | — | C/C | Medium | Medium |
| MDA-MB-231 | SS | T/T | Low | Medium |
| T47D | SL | T/T | Low | Medium |
| ML-1 | SL | T/T | High | Low |
| CCRF-CEM | SS | T/T | Medium | Low |
| TK6 | SS | T/T | Medium | Low |
| Jurkat | SS | C/C | Medium | Low |
| HS-5 | SS | T/T | Low | Low |
Abbreviations: Promoter polymorphism SS–short alleles (CA)11–12/(CA)11–12, SL – short/long alleles (CA)11–12/(CA)13–20, LL – long/long alleles (CA)13–20/(CA)13–20; for active site T2444C SNP C/C is a variant/variant. Low-medium-high classification based on mean±s.d.