Table 4. Progression-free survival: indirect comparison of sunitinib vs bevacizumab plus IFN.
Comparison | Input data | HR (95% CI) | P-value |
---|---|---|---|
Sunitinib vs IFN | Motzer: HR=0.538; SE[ln(HR)]=0.103 | 0.538 (0.439, 0.658) | <0.0001* |
Bevacizumab vs IFN | {AVOREN: HR=0.630; SE[ln(HR)]=0.093 CALGB: HR=0.710; SE[ln(HR)]=0.079} | 0.676 (0.601, 0.760) | <0.0001* |
Sunitinib vs bevacizumab | [Indirect comparison] | 0.796 (0.630, 1.004) | 0.0272* |
Abbreviations: HR=hazard ratio; IFN=interferon.
Based on 100 000 MCMC iterations.*One-tailed P-values.