Table 3. Results of multivariate analysis for progression-free and overall survival.
| Hazard ratio | 95% CI | P-value | |
|---|---|---|---|
| Progression-free survival | |||
| BRAF (mutant vs WT*) | 4.0 | (2.2, 7.4) | <0.0001 |
| Age (>65 vs ⩽65 years) | 1.4 | (1.0, 2.0) | 0.06 |
| Tumour grade (3 vs 1–2) | 1.5 | (1.0, 2.2) | 0.06 |
| Metastatectomy (yes vs no) | 0.6 | (0.4, 1.1) | 0.08 |
| Tumour location (colon vs rectum) | 1.6 | (1.0, 2.4) | 0.05 |
| Number of treatment lines (1 vs >3) | 0.3 | (0.2, 0.5) | <0.0001 |
| Number of treatment lines (2 vs >3) | 0.9 | (0.6, 1.3) | 0.5 |
| Overall survival | |||
| BRAF (mutant vs WT) | 4.1 | (2.1, 8.0) | <0.0001 |
| Age (>65 vs ⩽65 years) | 1.5 | (1.0, 2.4) | 0.07 |
| Tumour grade (3 vs 1–2) | 1.3 | (0.8, 2.1) | 0.3 |
| Metastatectomy (yes vs no) | 0.6 | (0.3, 1.3) | 0.2 |
| Stage at diagnosis (I–III vs IV) | 1.3 | (0.8, 2.0) | 0.2 |
| Tumor location (colon vs rectum) | 1.8 | (0.9, 3.3) | 0.08 |
| Number of lines of treatment (1 vs ⩾3) | 1.8 | (0.98, 3.3) | 0.06 |
| Number of lines of treatment (2 vs ⩾3) | 1.4 | (0.8, 2.3) | 0.3 |
CI=confidence interval; WT=wild type.