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. 2009 Jul 14;101(3):424–431. doi: 10.1038/sj.bjc.6605184

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Copyright © 2009 Cancer Research UK

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Assembly of cap-dependent initiation complex in mesothelioma is impaired by the production of constitutively active 4E-BP1 (4E-BP1^A37/A46). (A) An assessment of eIF4F integrity utilising a cap-affinity assay of four mesothelioma cell lines ectopically expressing the 4E-BP1^A37/A46 protein or control. Top, steady state levels of exogenous HA-tagged 4E-BP1^A37/A46 and endogenous 4E-BP1 in cells. Bottom, eIF4E and binding partners eIF4G and 4E-BP1^A37/A46 eluted from 7-methyl-GTP-sepharose resin. (B) The average and s.d. for the 4 MM cell lines, relative level of eIF4G normalised to eIF4E bound to the cap analogue comparing cells expressing and not expressing 4E-BP1^A37/A46.