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. 2009 Jul 14;101(3):424–431. doi: 10.1038/sj.bjc.6605184

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Copyright © 2009 Cancer Research UK

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Xenograft tumour growth is abrogated by constitutively active 4E-BP1. (A) tumour size for 10 animals (mean±s.e.) from cell lines H2373 and H2596 expressing (filled columns) or not expressing (open columns) 4E-BP1^A37/A46. Columns, the mean of five xenograft measurements of each cell line, bars, s.e. (B) immunoblot analysis of lysates from mesothelioma cells producing or not producing 4E-BP1^A37/A46 both before (in vitro) and after implantation (xenograft) into the mice. The level of ectopic HA-tagged 4E-BP1 is shown.