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. 2009 Jul 21;101(3):418–423. doi: 10.1038/sj.bjc.6605092

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Copyright © 2009 Cancer Research UK

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Treatment with ZD4190 reduced the area and microvascularity of tumour foci in a muscle model of minimal residual carcinoma. ZD4190 reduced (A) the tumour area at day 22 when more than 10⁵ PDVC57B cells were implanted to create each tract in the rectus and gastrocnemius muscles for groups of mice (n=5) and (B) the MVD of the tracts that developed in the gastrocnemius at day 9 and at both sites at day 22.