Skip to main content
. 2009 Aug 1;23(15):1763–1778. doi: 10.1101/gad.1808809

Figure 6.

Figure 6.

Disrupting HTP-3 or HTP-1/2 rescues spo-11, but depleting HIM-3 does not. (A) htp-3(y428) reduces the embryonic lethality of spo-11(me44). (A,B) Similar levels of hatching occur in the progeny of htp-3(y428); spo-11(me44) double mutants (A) and htp-3(y428) single mutants (B). Depletion of HTP-3 in htp-3(y428) mutants does not notably increase embryonic lethality. Thus, y428 is a null or strong loss-of-function allele. (C) HTP-3 and HTP-1/2 depletion suppress spo-11(me44), but HIM-3 depletion does not. (D) HIM-3 depletion results in much higher embryonic lethality than depletion of HTP-3 or HTP-1/2. (E) Synergistic embryonic lethality occurs in the broods of htp-3; rec-8 double mutants, implying that HTP-3 is not required for association of all REC-8•cohesin with meiotic chromosomes.