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. Author manuscript; available in PMC: 2009 Aug 3.
Published in final edited form as: Neurobiol Dis. 2008 Dec 31;34(1):95–106. doi: 10.1016/j.nbd.2008.12.007

Fig. 8.

Fig. 8

The effects of a JNK inhibitor on MCP-1 expression and AP-1 reporter gene activity induced by Aβ peptides. Panel A: hCMEC/D3 cultures were treated with Aβ1–40 or control peptides for 4 h in the presence or absence of the JNK inhibitor SP600125 (30 µM). Lipopolysaccharide (LPS) was used as a positive control. MCP-1 expression in hCMEC/D3 induced by Aβ1–40 or LPS was inhibited by JNK (*p < 0.01 as compared controls; #p < 0.01 as compared to Aβ- or LPS treated cells). Panel B: The effect of the JNK inhibitor SP600125 on AP-1 reporter gene assays in HEK293 cells treated with Aβ1–40 peptides (*p < 0.01 as compared to control; # p < 0.01 as compared to Aβ-treated cells).