Table 3.
Socio-demographic, lifestyle, health and biochemical measures associated with the allelic distribution of rs1130864 SNP
| CRP1444-rs1130864 |
OR |
OR |
|||
|---|---|---|---|---|---|
| CC (n = 1808) | CT (n = 1548) | TT (n = 344) | CT/CC (95% CI) | TT/CC (95% CI) | |
| Age (years), n (%) | |||||
| 70–74 | 651 (36.0) | 573 (37.0) | 140 (40.7) | 1 (Reference) | 1 (Reference) |
| 75–79 | 792 (43.8) | 672 (43.4) | 133 (38.7) | 0.96 (0.83–1.12) | 0.78 (0.60–1.01) |
| 80–84 | 294 (16.3) | 246 (15.9) | 59 (17.1) | 0.95 (0.78–1.16) | 0.93 (0.67–1.30) |
| ≥85 | 71 (3.9) | 57 (3.7) | 12 (3.5) | 0.91 (0.63–1.32) | 0.79 (0.41–1.49) |
| NESB, n (%)a | 231 (12.9) | 200 (13.0) | 50 (14.6) | 1.01 (0.82–1.24) | 1.16 (0.83–1.61) |
| Education: completed high school, n (%)b | 884 (49.0) | 740 (47.8) | 159 (46.2) | 0.96 (0.83–1.09) | 0.90 (0.71–1.13) |
| BMI, n (%)c | |||||
| <25 | 614 (34.1) | 515 (33.4) | 111 (32.5) | 1 (Reference) | 1 (Reference) |
| 25–29.9 | 909 (50.4) | 786 (51.0) | 174 (50.9) | 1.03 (0.89–1.20) | 1.06 (0.82–1.37) |
| ≥30 | 279 (15.5) | 240 (15.6) | 57 (16.7) | 1.03 (0.83–1.26) | 1.13 (0.80–1.60) |
| Smoker (current), n (%) | 103 (5.7) | 70 (4.5) | 18 (5.2) | 0.78 (0.57–1.07) | 0.91 (0.55–1.53) |
| Depression, n (%) | 101 (5.6) | 65 (4.2) | 16 (4.6) | 0.74 (0.54–1.02) | 0.82 (0.48–1.42) |
| GDS score, median (IQR) | 2 (1, 3) | 2 (1, 3) | 1 (1, 3) | 0.97 (0.94–1.00) | 0.97 (0.92–1.03) |
| PCS, n (%)d | |||||
| ≥50 | 437 (24.4) | 354 (23.0) | 82 (23.9) | 1 (Reference) | 1 (Reference) |
| 30–49.9 | 1063 (59.4) | 947 (61.6) | 212 (61.8) | 1.10 (0.93–1.30) | 1.06 (0.80–1.40) |
| <30 | 290 (16.2) | 237 (15.4) | 49 (14.3) | 1.01 (0.81–1.26) | 0.90 (0.61–1.32) |
| CRP, geometric mean (SD), (mg/l) | 1.8 (2.8) | 2.1 (2.9) | 2.5 (2.8) | 1.12 (1.05–1.19)e | 1.31 (1.17–1.46)f |
| CRP concentration (mg/l), n (%) | |||||
| <1 | 498 (27.5) | 350 (22.6) | 54 (15.7) | 1 (Reference) | 1 (Reference) |
| 1–2.9 | 771 (42.6) | 684 (44.2) | 155 (45.1) | 1.26 (1.06–1.50)g | 1.85 (1.33–2.58)h |
| ≥3 | 539 (29.8) | 514 (33.2) | 135 (39.2) | 1.36 (1.13–1.63)i | 2.31 (1.65–3.24)j |
aInformation missing for 21 participants.
bInformation missing for 4 participants.
cInformation missing for 15 participants.
dInformation missing for 29 participants.
ez-statistic = 3.31, P = 0.001.
fz-statistic = 4.77, P < 0.001.
gz-statistic = 2.67, P = 0.008.
hz-statistic = 3.67, P < 0.001.
iz-statistic = 3.28, P = 0.001.
jz-statistic = 4.85, P < 0.001.
IQR = interquartile range.