Table 4.
Socio-demographic, lifestyle, health and biochemical measures associated with the allelic distribution of rs1205 SNP
| CRP1846-rs1205 |
OR |
OR |
|||
|---|---|---|---|---|---|
| GG (n = 1630) | GA (n = 1667) | AA (n = 403) | GA/GG (95% CI) | AA/GG (95% CI) | |
| Age (years), n (%) | |||||
| 70–74 | 602 (36.9) | 622 (37.3) | 140 (34.7) | 1 (Reference) | 1 (Reference) |
| 75–79 | 716 (43.9) | 706 (42.3) | 175 (43.4) | 0.95 (0.82–1.11) | 1.05 (0.82–1.35) |
| 80–84 | 260 (15.9) | 265 (15.9) | 74 (18.4) | 0.99 (0.80–1.21) | 1.22 (0.89–1.68) |
| ≥85 | 52 (3.2) | 74 (4.4) | 14 (3.5) | 1.38 (0.95–2.00) | 1.16 (0.62–2.15) |
| NESB, n (%)a | 210 (12.9) | 212 (12.8) | 59 (14.7) | 0.99 (0.81–1.22) | 1.16 (0.85–1.58) |
| Education: completed high school, n (%)b | 795 (48.8) | 788 (47.4) | 200 (49.6) | 0.94 (0.82–1.08) | 1.03 (0.83–1.29) |
| BMI, n (%)c | |||||
| <25 | 534 (32.9) | 566 (34.1) | 140 (34.8) | 1 (Reference) | 1 (Reference) |
| 25–29.9 | 830 (51.1) | 834 (50.3) | 205 (51.0) | 0.95 (0.81–1.10) | 0.94 (0.74–1.20) |
| ≥30 | 261 (16.1) | 258 (15.6) | 57 (14.2) | 0.93 (0.76–1.15) | 0.83 (0.59–1.17) |
| Smoker (current), n (%) | 76 (4.7) | 91 (5.5) | 24 (6.0) | 1.18 (0.86–1.61) | 1.29 (0.81–2.08) |
| Depression, n (%) | 75 (4.6) | 77 (4.6) | 30 (7.4) | 1.00 (0.72–1.39) | 1.67 (1.08–2.58)e |
| GDS score, median (IQR) | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) | 1.01 (0.98–1.04) | 1.05 (1.01–1.10)f |
| PCS, n (%)d | |||||
| ≥50 | 404 (24.9) | 377 (22.8) | 92 (23.0) | 1 (Reference) | 1 (Reference) |
| 30–49.9 | 972 (60.0) | 1009 (61.1) | 241 (60.2) | 1.11 (0.94–1.31) | 1.09 (0.83–1.42) |
| <30 | 244 (15.1) | 265 (16.0) | 67 (16.7) | 1.16 (0.93–1.46) | 1.21 (0.85–1.72) |
| CRP, geometric mean (SD), (mg/l) | 2.3 (2.8) | 1.8 (2.9) | 1.6 (2.6) | 0.81 (0.75–0.86)g | 0.66 (0.59–0.74)h |
| CRP concentration (mg/l), n (%) | |||||
| <1 | 306 (18.8) | 465 (27.9) | 131 (32.5) | 1 (Reference) | 1 (Reference) |
| 1–2.9 | 713 (43.7) | 721 (43.2) | 176 (43.7) | 0.67 (0.56–0.79)i | 0.58 (0.44–0.75)j |
| ≥3 | 611 (37.5) | 481 (28.8) | 96 (23.8) | 0.52 (0.43–0.62)k | 0.37 (0.27–0.49)l |
aInformation missing for 21 participants.
bInformation missing for 4 participants.
cInformation missing for 15 participants.
dInformation missing for 29 participants.
ez-statistic = 2.29, P = 0.022.
fz-statistic = 2.18, P = 0.029.
gz-statistic = 4.11, P < 0.001.
hz-statistic = 7.02, P < 0.001.
iz-statistic = 4.50, P < 0.001.
jz-statistic = 6.62, P < 0.001.
kz-statistic = 4.85, P < 0.001.
lz-statistic = 6.62, P < 0.001.
IQR = interquartile range.