Fig. 2.

The CD44⁺/CD24^−/low-MS gene signature is enriched in human breast tumors of the claudin-low molecular subtype. (A) Correlation (R value, see Methods) between the CD44⁺/CD24^−/low-MS signature pattern and each tumor in the gene expression profile dataset by Herschkowitz et al. (6) (claudin-low, basal, ERBB2+, luminal, normal-like; averages centered on the mean centroid of the groups). R values above red dotted line are significant at P < 0.00001. (B) Scatter plot of CD24 versus CD44 mRNA expression for the Herschkowitz tumors. (C) Heat map of the corresponding patterns of the CD44⁺/CD24^−/low-MS signature genes within the Herschkowitz tumors. The order of the Herschkowitz tumors is the same for A and C; the order of the genes is the same across datasets.